A delivery platform to turn
nucleic acids into therapeutic solutions
lipopolymers for delivering nucleic acids into cells
Combinations of lipids and polymers for effective delivery of nucleic acids: optimized for size, composition, stability, and architecture.
Superior to current delivery vehicles
Mechanism of action
for lipopolymer-mediated nucleic acid delivery
for different applications
I. Different cell types
II. Different nucleic acids
transfecting attachment-independent K562 cells with plasmid DNA and siRNA using ALLFect and a leading lipofection reagent.
A) GFP expression was induced with plasmid DNA and analyzed by flow cytometry 2 days after transfection.
B) Survivin silencing and resultant inhibition of cell growth with specific siRNA 3 days after transfection.
in animal models
I. Expression of reporter GFP gene in implants with pDNA
II. Repair of bone (skull) defects with implantation of pDNA
III. Inhibition of tumor growth with siRNA injections
IV. Inhibition of tumour growth with local mRNA injections
Weight of explanted breast cancer tumors (day 17) for nontreated (NT), GFP and TRAIL expressing mRNAs. * and ** indicate significant differences between TRAIL mRNA and mGFP and NT groups.