Transfection Reagents

In Vivo DNA-Fect:
pDNA Transfection Reagent

$400.00$720.00 CAD

  • For pDNA administration in animal models
  • Cost-effective for in vivo applications, with improved transfection efficiency and minimal toxicity
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In Vivo DNA-Fect:

In Vivo DNA-Fect is a highly effective delivery agent for use in animal studies. In Vivo DNA-Fect is a synthetic amphiphilic polymer that is specifically tailored for plasmid DNA delivery. It is capable of undergoing multivalent interactions with DNA and encapsulating co-incubated DNA molecules into 100-150 nm particles with a net positive charge. The complexation between the plasmid DNA and In Vivo DNA-Fect occurs in aqueous buffers, obviating the need for organic solvents during preparation. In Vivo DNA-Fect is a non-integrating carrier of DNA, so that the genetic make-up of host cells is not altered after treatment with the delivery reagent. In Vivo DNA-Fect has been tested and found effective in different types of attachment dependent cells as well for cell culture use, but users are advised to test the efficacy of the reagent with their particular cell type to confirm utility in specific applications. As with all delivery agents, formulations of In Vivo DNA-Fect with plasmid DNA may need to be optimized for specific applications in vivo.

Overview:

Property In Vivo DNA-Fect
Nucleic Acid pDNA
Transfection Type Transient, In Vivo
High Throughput Compatible
Buffer Aqueous
Storage Temperature -20ºC
Shelf Life at -20ºC 1 year

References

Rose et al., Biomaterials Science (2014) 2: 833-842.
Rose et al., Biomaterials (2012) 33: 3363-3374.

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